The game revolves around a bald assassin, named Agent 47, assassinating targets for an organization named the International Contract Agency (also known as “The Agency”). During these assassinations, the player, controlling Agent 47, can acquire, and use, many different weapons straining from semi-automatic pistols to rapid-fire rifles, and can complete any mission in any way they want to.
The player is provided with a briefing, some intelligence on the target, a map of the surrounding area the target will be, and a list of multiple weapons. The briefing is conducted by an anonymous controller at the Agency, by the alias of Diana Burnwood, and usually gives the player a decent gist of everything concerning who you need to assassinate, why he needs to be assassinated, and a shopping list of the available weaponry. The intelligence is usually a target image and video, along with information including height, weight, and other details about the target. The map and weapons vary on the mission; as the mission Plutonian Runs Loose allows the player to buy a minigun in Rotterdam, while the mission The Lee Hong Assassination only allows the player to use a smaller list weapons that can be used into Hong Kong.